Radical prostatectomy for high-risk prostate cancer
November 19th, 2009 Posted in prostatectomyThe prostate-specific antigen (PSA) era has changed the pattern of prostate cancer at presentation. Patients now present with lower-stage, lower-risk disease. However, some patients continue to present with high-risk prostate cancer (high-risk PC), and the effect of PSA introduction on outcome is less clear.
A new review at Department of Urology, Mayo Clinic highlights the salient features of why radical prostatectomy should be considered in the management of men with high-risk PC (Gleason score 8-10, marked increase in PSA levels and advanced clinical T stage). Radical retropubic prostatectomy (RRP) can provide durable local control, long-term cancer-specific survival and accurate pathologic staging, and may guide further individualized treatment. For these reasons, RRP remains the best single treatment of high-risk PC in operable patients.