Effect of androgen deprivation therapy on body composition in men with prostate cancer
February 4th, 2010 Posted in prostate cancerUse of androgen deprivation therapy is associated with changes in body composition including increased fat and decreased lean mass. Limited information exists regarding the rate and extent of these changes.
A recent study at Queen’s University Belfast, Belfast, Northern Ireland, UK, evaluated the use of androgen deprivation therapy (ADT) in the treatment of prostate cancer. This systematic review was conducted to determine the effects of ADT on body composition in prostate cancer patients.
The study revealed that significant increases in fat and declines in lean mass were observed in prostate cancer patients treated with ADT. Lifestyle changes or suitable interventions to minimize the effect of ADT on body composition need to be investigated.
According to research team prostate cancer survivors should be made aware of the side effect of treatment on body composition. However, further work is required to determine what interventions can minimize the impact of ADT on body composition and therefore what evidence based advice they should be provided with. In general, though recommendation of a healthy diet and moderate exercise is reasonable.