Diagnosis of prostate cancer by detection of minichromosome maintenance 5 protein in urine sediments
July 26th, 2010 Posted in prostate cancer diagnosisPrevious studies suggested the accuracy of prostate-specific antigen (PSA) testing in prostate cancer detection is constrained by low sensitivity and specificity. Dysregulated expression of minichromosome maintenance (Mcm) 2–7 proteins is an early event in epithelial multistep carcinogenesis and thus MCM proteins represent powerful cancer diagnostic markers.
A recent study aimed to investigate Mcm5 as a urinary biomarker for prostate cancer detection.
Rersearchers concluded urinary Mcm5 detection seems to be a simple, accurate and noninvasive method for identifying patients with prostate cancer. Large-scale prospective trials are now required to evaluate this test in diagnosis and screening.
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