Stiffening of the large arteries in men receiving antiandrogen therapy
February 19th, 2009 Posted in hormone therapyA new research shown that antiandrogen treatment (with bicalutamide) in men with prostate cancer may increase stiffness of the large arteries, which is an adverse cardiovascular risk factor.
The also noted that this effect was not maintained with testosterone receptor blockade (with goserelin acetate) in the longer term but tended to be sustained with suppression therapy. This adverse reaction may have some association to different effects of the two therapies on levels of sex hormones.