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A Better Blood Test For Prostate CancerCurrent standards of screening and testing for prostate cancer focus on the blood protein prostate-specific antigen (PSA) along with a digital rectal examination. Men who have more than 2.5 nanograms per milliliter of PSA are considered at risk for prostate cancer. However, PSA testing often erroneously highlights noncancerous conditions (false positives) and can miss some cases of cancer (false negatives), according to Robert H. Getzenberg, Ph.D., professor of urology and director of research at the James Buchanan Brady Urological Institute at The Johns Hopkins University School of Medicine. Due to elevated PSA levels, approximately 1.6 million men undergo prostatic biopsies in the United States annually, and roughly 80 percent of these men have negative results, according to Getzenberg, lead author of the study. He says that of the entire population of men in the United States who have been tested for PSA, an estimated 25 million have elevated PSA levels and a biopsy of the prostate that did not reveal any prostate cancer. Conversely, roughly 15 percent of men with prostate cancer go undetected because their PSA levels are below the cutoff level, according to Getzenberg. In a study published in the April issue of the journal Urology, Getzenberg and a team of Hopkins researchers introduce evidence in support of EPCA-2 testing as a more accurate way to identify cancer in the prostate. "A blood test based on EPCA-2 may greatly improve our ability to accurately detect prostate cancer early and minimize the number of false positives, therefore lowering the number of unnecessary biopsies," says Getzenberg. "In addition, this is the first time we have a test that effectively distinguishes between men with cancer confined to the prostate and those whose disease has spread outside of the gland." NOTE: Issues on this site regarding men's health and their concerns, are provided for information only, and are not meant to substitute for the advice of your own physician or other medical professional. Prostate-Report.org does not endorse any specific product, service or treatment. |
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